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AMP stands for Antibody Mediated Prevention. This is the idea of giving people antibodies to see if they will protect people from getting infected with HIV.

The AMP study is a new idea for HIV prevention that is related to what has been done in HIV vaccine research. In traditional HIV vaccine studies, people get a vaccine and researchers wait to see if their bodies will make antibodies against HIV in response. In this study, we will skip that step, and give people the antibodies directly. We will do this with an intravenous infusion, commonly known as an “IV” or “getting a drip”. This is the first study testing whether antibodies can prevent HIV infections in people.

The Give PrEP A Shot study is testing whether a long-acting form of the anti-HIV drug cabotegravir injected once every 8 weeks can safely protect people from HIV infection at least as well as taking Truvada as PrEP, an daily oral tablet.

As of today Truvada is the only medication currently approved for PrEP (HIV pre-exposure prophylaxis).

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